Exosomal miR-30a-5p targets NLRP3 to suppress podocyte pyroptosis in diabetic nephropathy
نویسندگان
چکیده
منابع مشابه
Drug Targets for Oxidative Podocyte Injury in Diabetic Nephropathy.
Diabetic nephropathy (DN) is one the most prevalent chronic complications of diabetes mellitus that affects as much as one-third of diabetic patients irrespective of the type of diabetes. Hyperglycemia is the key trigger for DN that initiates a number of microscopic and ultramicroscopic changes in kidney architecture. Microscopic changes include thickening of the glomerular basement membrane (G...
متن کاملUrinary Exosomal MicroRNAs in Incipient Diabetic Nephropathy
MicroRNAs (miRNAs), a class of small non-protein-encoding RNAs, regulate gene expression via suppression of target mRNAs. MiRNAs are present in body fluids in a remarkable stable form as packaged in microvesicles of endocytic origin, named exosomes. In the present study, we have assessed miRNA expression in urinary exosomes from type 1 diabetic patients with and without incipient diabetic nephr...
متن کاملmiR-125a-5p is a prognostic biomarker that targets HDAC4 to suppress breast tumorigenesis
Identifying stably expressed tumor markers that can be used easily to detect cancer is currently an important area of cancer research. By using miRNA microarray, we identified 20 differentially expressed miRNAs in serum samples of breast cancer patients. Expression of miR-125a-5p was relatively lower in patients with shorter survival compared to long-term survivors. In a cohort of breast cancer...
متن کاملRegulation of podocyte lesions in diabetic nephropathy via miR-34a in the Notch signaling pathway
BACKGROUND The activation of the Notch signaling pathway has been shown to play an important role in diabetic nephropathy (DN) development. Besides, Notch-1 is a target gene in miR-34a. However, the regulation of the podocyte lesions involved in DN by miR-34a has not been identified. METHODS This study utilized miR-34a mimics and small interfering RNA transfection to construct miR-34a overexp...
متن کاملMiR-30a inhibits BECN1-mediated autophagy in diabetic cataract
Purpose To investigate the role of microRNAs in the regulation of autophagy and apoptosis in lens epithelial cells (LECs) during diabetic cataract formation. Methods A miRNA microarray study and quantitative real-time PCR were performed to identify the expression of miRNAs in LECs of diabetic cataract. Human LECs were cultured in high glucose conditions as a diabetic cataract model. BECN1 and...
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ژورنال
عنوان ژورنال: Biocell
سال: 2023
ISSN: ['0327-9545', '1667-5746']
DOI: https://doi.org/10.32604/biocell.2023.024591